Gene name:
Eif2ak3 (Pek;Perk) ;
Protein name:
Eukaryotic translation initiation factor 2-alpha kinase 3 ;
Alternative:
Pancreatic eIF2-alpha kinase ;PRKR-like endoplasmic reticulum kinase ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with DNAJC3 (By similarity). Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells.
Function:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MERATQPRPR | ALLLLFLLLG | CAAGISAVAR | ARSLLAPTSD | TAFGLGAAAA |
100:
PTSAARVPAV | ATAEVTVEDA | EALPAASGEQ | ESRATESDDD | VELRPRGRSL |
150:
VIISTLDGRI | AALDAENHGK | KQWDLDVGSG | SLVSSSLSKP | EVFGNKMIIP |
200:
SLDGDLFQWD | RDRESMEAVP | FTVESLLESS | YKFGDDVVLV | GGKSLTTYGL |
250:
SAYSGKLRYI | CSALGCRRWD | SDEMEEEEDI | LLLQRTQKTV | RAVGPRSGSE |
300:
KWNFSVGHFE | LRYIPDMETR | AGFIESTFKL | GGNKEDSKII | SDVEEQDVDT |
350:
VIKVSVADWK | VMAFSKKGGR | LEWEYQFCTP | IASAWLVRDG | KVIPISLFDD |
400:
TSYTANEEVL | EDEEDIVEAA | RGATENSVYL | GMYRGQLYLQ | SSVRVSEKFP |
450:
TRPKALESVN | GESAIIPLPT | IKWKPLIHSP | SRTPVLVGSD | EFDKCLSNDK |
500:
YSHEEYSNGA | LSILQYPYDN | GYYLPYYKRE | RNKRSTQITV | RFLDSPHYSK |
550:
NIRKKDPILL | LHWWKEIFGT | ILLCIVATTF | IVRRLFHPQP | HRQRKESETQ |
600:
CQTESKYDSV | SADNSDNSWN | DIKHSGYVSR | YLTDFEPIQC | MGRGGFGVVF |
650:
EAKNKVDDCN | YAIKRIRLPN | RELAREKVMR | EVKALAKLEH | PGIVRYFNAW |
700:
LETPPEKWQE | EMDEIWLKDE | STDWPLSSPS | PMDAPSVKIR | QMDPFSTKEQ |
750:
IEVIAPSPER | SRSFSVGISC | GRTSSSESQF | SPLEFSGTDC | GDNSDSEDAA |
800:
HNLQDSCLTD | CDMEDGTVDG | DDEGHSFELC | PSEASPYTRS | REGTSSSIVF |
850:
EDSGCDNASS | KEDPRMNRLH | NGHHYVNKLT | EFKHSSSRSS | SEATLSTSPT |
900:
RPTTLSLDFT | RNTVDRLQPS | SPKVYLYIQM | QLCRKENLKD | WMNRRCSMED |
950:
REHRVCLHIF | LQIAEAVQFL | HSKGLMHRDL | KPSNIFFTMD | DVVKVGDFGL |
1000:
VTAMDQDEEE | QTVLTPMPAY | ATHTGQVGTK | LYMSPEQIHG | NNYSHKVDIF |
1050:
SLGLILFELL | YPFSTQMERV | RTLTDVRNLK | FPPLFTQKYP | QEHMMVQDML |
1100:
SPSPMERPEA | TDIIENAVFE | NLEFPGKTVL | RQRSRSLSSS | GTKHSRQPSS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
ELISA Kit for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
ELISA Kit for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
CLIA Kit for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
CLIA Kit for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
CLIA Kit for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Protein for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Protein for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Protein for Rat Eukaryotic translation initiation factor 2-alpha kinase 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
tissue :
Pancreatic islet .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF LYS-614
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT